Current Issue : October-December Volume : 2014 Issue Number : 4 Articles : 2 Articles
Aim of the present study was to determine whether agomelatine could affect ethanol withdrawal-induced depression-like behavior through M1/M2 receptor agonist, serotonin 5-HT2c antagonist and 5-HT1-A agonist in mice. This study investigated the role of a melatonergic M1/M2 receptor agonist, serotonin 5-HT2C antagonist and 5-HT1-A agonist. Novel anti depressant agomelatine, melatonin and their combine effect with 5-HT1-A agonist 8-OH DPAT on ethanol withdrawal induced depression using tail suspension (TST) test in mice. Male mice received an ethanol-containing (1.6%, 3.6%, 6.3%) liquid diet for 10 days and were tested for withdrawal signs and symptoms at 2, 4, 6, 8, 10 h after termination of the diet on day 11. Agomelatine, melatonin and diazepam significantly reduced these signs of hyper excitability (EWS). The depression effect of ethanol withdrawal was attenuated by treatment with melatonin (10mg/kg), agomelatine (50 mg/kg, i.p.), 8-OH DPAT (1 mg/kg, i.p.). Ethanol-withdrawn mice treated with, melatonin and 8-OH DPAT displayed decreased duration of immobility than ethanol control mice. Agomelatine was more potent than Melatonin in reversing ethanol withdrawal-induced increase in duration of immobility. Agomelatine combination with 8-OH DPAT was more potent than given alone. Locomotor activity was unchanged in all treated groups compared to control groups. In conclusion, agomelatine was shown to possess antidepressant effects in the mice TST and melatonergic agonist, 5-HT2C antagonist and 5-HT1-A agonist properties could be involved in these effects....
The study was carried out on 48 layer birds of above 2 months age that were divided into six groups consisting of 8 in each. Group 1 served as control, group 2 was treated with imidacloprid @ 200 ppm in feed, group 3 was treated with vitamin C @ 200 ppm in feed, group 4 was treated with both imidacloprid@200ppm and vitamin C 200ppm, group 5 was treated with Withania somnifera @ 500 ppm in feed and group 6 was treated with imidacloprid @ 200 ppm in feed + Vitamin C @ 200 ppm in feed + Withania somnifera @ 500 ppm in feed. Moderate immunosuppression was exhibited in both humeral as well as cell mediated immunities. The above study concluded that Imidacloprid insecticide has immunological deleterious effects in chickens targeting the humeral and cell mediated immune responses and vitamin E and selenium supplementation decreased the ill effects of Imidacloprid....
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